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[Histamine in tears in allergic rhinoconjunctivitis]

H G Struck1, A Wicht, K Pönicke

  • 1Klinik und Poliklinik für Augenheilkunde, Martin-Luther-Universität, Halle-Wittenberg.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|June 12, 1998
PubMed
Summary

Histamine levels in tears increase significantly during allergy season in patients with allergic conjunctivitis. However, tear histamine alone does not correlate with symptom severity or treatment effectiveness, suggesting it

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Area of Science:

  • Ophthalmology
  • Allergology
  • Clinical Chemistry

Context:

  • Allergic conjunctivitis involves histamine release, causing symptoms like itching and lacrimation.
  • Measuring tear histamine may offer insights into local allergic reactions.

Purpose:

  • To investigate the correlation between tear histamine levels and clinical symptoms in allergic conjunctivitis patients.
  • To assess the utility of tear histamine as a biomarker for atopy severity and treatment efficacy.

Summary:

  • A study analyzed tear histamine levels in 32 allergic conjunctivitis patients and 32 controls during and out of pollen season.
  • Histamine levels significantly increased in allergic patients during the season, correlating with atopy severity but not clinical symptoms.
  • Control group tear histamine levels were undetectable.

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Impact:

  • Tear histamine levels alone are insufficient as a marker for clinical severity or treatment efficacy in allergic conjunctivitis.
  • Future research may utilize tear histamine as part of a broader mediator profile for evaluating clinical symptoms.