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Related Experiment Videos

Allograft bone transplantation: a Sheffield experience

M T Khan1, I Stockley, C Ibbotson

  • 1Department of Orthopaedics, Northern General Hospital, Sheffield.

Annals of the Royal College of Surgeons of England
|June 12, 1998
PubMed
Summary

Demand for bone allografts is rising for bony defect repair. Strict screening protocols in tissue banks, like Sheffield Tissue Bank, minimize infection risks and ensure safe allograft bone transplantation.

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Area of Science:

  • Orthopedics
  • Tissue Banking
  • Transplantation

Background:

  • Bone allografts are increasingly utilized for reconstructing bony defects.
  • Allograft bone transplantation carries a risk of infection transmission.
  • Tissue banks require stringent processing and donor/recipient screening protocols.

Purpose of the Study:

  • To outline the experience, challenges, and successes of the Sheffield Tissue Bank.
  • To demonstrate the safety and efficacy of bone allografts when processed under strict protocols.
  • To highlight the importance of donor and recipient databases in preventing disease transmission.

Main Methods:

  • Established in 1989, the Sheffield Tissue Bank implemented rigorous screening protocols for bone donors.
  • Maintained a comprehensive donor and recipient database.

Related Experiment Videos

  • Processed and stored bone allografts for various surgical applications.

    • Main Results:

    • Between 1989 and 1993, 220 patients received bone allografts.
    • Allografts were primarily used for revision hip/knee arthroplasty and scoliosis surgery.
    • No cases of disease transmission were reported, and infection rates were minimized.

    Conclusions:

    • Strict screening protocols effectively reduce infection risks associated with bone allografts.
    • The Sheffield Tissue Bank successfully provided safe bone allografts for patient treatment.
    • Human bone banking requires meticulous adherence to safety standards for successful outcomes.