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Predominant enteroviral serotypes causing meningitis

P J Atkinson1, M Sharland, H Maguire

  • 1Public Health Laboratory Service, Communicable Disease Surveillance Centre (Thames), London.

Archives of Disease in Childhood
|June 12, 1998
PubMed
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Enteroviruses are a common cause of viral meningitis. Analysis of UK laboratory data identified key enterovirus serotypes responsible for cerebrospinal fluid infections, suggesting a potential target for vaccines.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Enteroviruses are a significant cause of viral meningitis.
  • Accurate identification of causative serotypes is crucial for public health surveillance and vaccine development.

Purpose of the Study:

  • To analyze enteroviral isolates from cerebrospinal fluid (CSF) in the UK between 1975 and 1994.
  • To identify the most prevalent enterovirus serotypes causing meningitis.

Main Methods:

  • Retrospective analysis of enteroviral reports submitted to the Public Health Laboratory Service.
  • Data included isolates confirmed by culture from CSF samples.

Main Results:

  • Over 40,000 enteroviral isolates were analyzed, with 5,741 (14%) from CSF cultures.

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  • Serotypes A9, E7, E9, E11, E19, and E30 accounted for 70% of CSF isolates.
  • These findings highlight specific serotypes as major contributors to enteroviral meningitis.
  • Conclusions:

    • A limited number of enterovirus serotypes are responsible for the majority of viral meningitis cases in the UK.
    • Development of an enteroviral vaccine targeting these prevalent serotypes could significantly reduce the burden of viral meningitis.