Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Leaf trajectory calculation for dynamic multileaf collimation to realize optimized fluence profiles

M L Dirkx¹, B J Heijmen, J P van Santvoort

¹University Hospital Rotterdam/Daniel den Hoed Cancer Center, The Netherlands. dirkx@kfih.azr.nl

Physics in Medicine and Biology

|June 12, 1998

Summary

This study presents an algorithm for precise intensity modulated radiation therapy beam profiles using dynamic multileaf collimation. The method accurately calculates leaf trajectories, minimizing dose errors for effective clinical application.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Individualized nonadaptive and online-adaptive intensity-modulated radiotherapy treatment strategies for cervical cancer patients based on pretreatment acquired variable bladder filling computed tomography scans.

International journal of radiation oncology, biology, physics·2012

Same author

Stereotactic body radiation therapy for colorectal liver metastases.

The British journal of surgery·2010

Same author

Electronic portal image assisted reduction of systematic set-up errors in head and neck irradiation.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2001

Same author

A linear diode array (JFD-5) for match line in vivo dosimetry in photon and electron beams; evaluation for a chest wall irradiation technique.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2001

Same author

A protocol for the reduction of systematic patient setup errors with minimal portal imaging workload.

International journal of radiation oncology, biology, physics·2001

Same author

Commissioning of a commercially available system for intensity-modulated radiotherapy dose delivery with dynamic multileaf collimation.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2001

Area of Science:

Medical Physics
Radiation Oncology
Radiotherapy Technology

Background:

Intensity modulated radiation therapy (IMRT) requires precise beam shaping.
Dynamic multileaf collimation (DMLC) is crucial for IMRT delivery.
Accurate calculation of leaf trajectories is essential for optimal fluence profile generation.

Purpose of the Study:

To develop and validate an algorithm for calculating leaf trajectories for optimized IMRT beam profiles using DMLC.
To account for physical factors like leaf transmission and collimator scatter.
To minimize tongue-and-groove underdosage effects in IMRT delivery.

Main Methods:

An iterative algorithm was developed to calculate required leaf trajectories.
The algorithm incorporates leaf transmission and collimator scatter.

Related Experiment Videos

Predicted dose distributions were compared with measured data from a Racetrack Microtron.

Main Results:

The algorithm requires a limited number of iterations (typically <10) for convergence.
Minimized differences between optimized and realized fluence profiles were achieved.
Agreement between predicted and measured absolute dose distributions was within 2% or 2 mm in high dose gradient regions.

Conclusions:

The developed algorithm accurately calculates leaf trajectories for DMLC.
The algorithm effectively minimizes underdosage effects.
The validated accuracy is suitable for clinical application in IMRT.