Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1,022 cases

S M Green1, S G Rothrock, E L Lynch

  • 1Department of Emergency Medicine, Loma Linda University School of Medicine, CA, USA.

Insights

Intramuscular ketamine is safe and effective for pediatric procedures in the emergency department. This study found minimal complications, with 98% of children receiving adequate sedation for procedures.

Area of Science:

  • Emergency Medicine
  • Pediatric Sedation
  • Pharmacology

Background:

  • Intramuscular ketamine is utilized for pediatric procedural sedation in emergency settings.
  • A defined protocol for administration is crucial for safety and efficacy.

Observation:

  • A case series of 1,022 pediatric patients receiving intramuscular ketamine (4 mg/kg) over 9 years.
  • Physician-reported data captured indications, sedation adequacy, and complications.
  • Chart review supplemented data on adverse reactions and discharge times.

Findings:

  • Transient airway complications (1.4%) and emesis (6.7%) were observed but managed without sequelae.
  • Agitation occurred in 19.2% of patients, with most cases being mild.
  • Ketamine provided acceptable sedation in 98% of pediatric patients, with a median discharge time of 110 minutes.

Implications:

  • Intramuscular ketamine can be safely administered by emergency physicians for pediatric procedures under protocol.
  • Ketamine offers a safe and effective sedation option, preserving airway reflexes and not requiring IV access.
  • Appropriate monitoring is essential for successful ketamine use in pediatric emergency care.
Abstract

Related Concept Videos

Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...