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Related Experiment Videos

Hemolysis caused by factor VIII concentrates

E P Orringer, M J Koury, P M Blatt

    Archives of Internal Medicine
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Immune hemolytic anemia can occur with factor VIII concentrate transfusions. This complication, often masked by bleeding, can be caused by antibodies in the concentrate, even at low titers.

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    Area of Science:

    • Hematology
    • Immunology
    • Transfusion Medicine

    Background:

    • Immune hemolytic anemia (IHA) is a known complication of factor VIII concentrate use.
    • Hemolysis can be masked by active bleeding, complicating diagnosis.
    • Previous cases attributed RBC destruction to anti-A antibodies in factor VIII concentrates.