Abnormal FSH hypersecretion as an endocrinological manifestation of POEMS syndrome

Two patients with POEMS syndrome had high basal levels of FSH in the absence of primary hypogonadism. They were fertile eugonadal men with normal serum testosterone and estradiol levels. Provocation with LH-releasing hormone revealed blunted response of FSH secretion, but normal response of LH secretion in both patients, and one had pituitary microadenoma on brain MRI. This report adds primary FSH hypersecretion in the absence of primary testicular failure to the list of endocrinopathy of POEMS syndrome.