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The effect of aqueous humor suppressants on intravitreal gas bubble duration in rabbits
1Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510, USA.
Purpose:
To evaluate the effect of topical aqueous humor suppressants on the absorption of intravitreal perfluorocarbon gases.
Methods:
Sulfur hexafluoride or perfluoropropane was injected intravitreally in five rabbits. Time to gas disappearance was measured in eyes treated with topical aqueous humor suppressants and in those not treated.
Results:
The mean time (+/- SD) to disappearance of 0.4 cc of sulfur hexafluoride was 5.6 +/- 0.9 days, which was prolonged by 43% to 8.0 +/- 0.7 days with topical aqueous humor suppressants (P = .009). The mean time (+/- SD) to disappearance of 0.2 cc of perfluoropropane was 18.4 +/- 1.9 days, which was prolonged by 55% to 28.6 +/- 2.7 days with topical aqueous humor suppressants (P = .009).
Conclusion:
Aqueous suppressants prolong sulfur hexafluoride and perfluoropropane intravitreal gas bubble duration in rabbits.