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A pilot study of nedaplatin and etoposide for recurrent gynecological malignancies
S Adachi1, T Ogasawara, N Yamasaki
1Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya city, Hyogo 663, Japan.
Abstract:
Nedaplatin is a new analogue of cisplatin with similar efficacy but less renal toxicity. We assessed the efficacy and toxicity of nedaplatin and etoposide for recurrent gynecological malignancies. Eight patients were treated with 100 mg/m2 of nedaplatin (day 1) and 70 mg/m2 of etoposide (days 1, 3, and 5 ) every 4 weeks. A total of 17 courses was given. Grade 3/4 leucopenia and thrombocytopenia occurred, but was manageable. The response rate was 37.5% (partial response n=3; no change n=4; progressive disease n=1). In conclusion, a phase II study of this regimen for recurrent gynecological malignancies is warranted.