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Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy
M Pérez1, J M Valpuesta, E M de Garcini
1Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid, Spain.
The American Journal of Pathology
|June 17, 1998
Abstract:
Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.