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Unknown primary tumors metastatic to liver
J P Ayoub1, K R Hess, M C Abbruzzese
1Department of Gastrointestinal Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.
Summary
Identifying prognostic factors for unknown primary tumor (UPT) patients with hepatic metastases is crucial. Chemotherapy may improve survival for adenocarcinoma patients with liver involvement.
Area of Science:
- Oncology
- Medical Research
Background:
- Unknown primary tumor (UPT) with hepatic metastases presents a significant clinical challenge.
- Identifying prognostic factors is essential for patient management and treatment strategies.
Purpose of the Study:
- To identify prognostic factors for UPT patients with liver metastases.
- To determine common primary tumor origins and assess diagnostic study yields.
- To evaluate the impact of therapy on survival outcomes.
Main Methods:
- Analysis of 1,522 patients diagnosed between 1987 and 1995.
- Utilized a computerized database for clinical data management.
- Employed Kaplan-Meier survival analysis and Cox proportional hazards regression.
Main Results:
- Of 500 UPT patients with liver metastases, primary tumors were identified in 27%.
- Hepatic metastases correlated with a higher mortality risk (HR, 1.63).
- Chemotherapy showed a survival benefit (HR, 0.52), particularly for adenocarcinoma.
Conclusions:
- Hepatic metastases in unknown primary carcinoma (UPC) patients generally indicate a poor prognosis.
- Clinical and pathological data can identify subsets with better outcomes.
- Chemotherapy may benefit UPC patients with liver adenocarcinoma.