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Mononeuropathies associated with liver transplantation

J V Campellone1, D Lacomis, M J Giuliani

  • 1Department of Medicine, Cooper Hospital/University Medical Center, Camden, New Jersey 08103, USA.

Muscle & Nerve
|June 17, 1998
PubMed
Summary

Peripheral nerve injuries, specifically mononeuropathies, affect 10% of liver transplant patients post-surgery. The ulnar nerve is most commonly impacted, often due to compression or trauma during or after the orthotopic liver transplantation procedure.

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Area of Science:

  • Neurology
  • Transplantation Surgery
  • Medical Research

Background:

  • Orthotopic liver transplantation (OLT) is a complex procedure with potential complications.
  • Peripheral nerve injuries can occur in the perioperative period, impacting patient outcomes.

Purpose of the Study:

  • To prospectively evaluate the incidence and characteristics of mononeuropathies following OLT.
  • To identify potential risk factors and mechanisms of nerve injury in liver transplant recipients.

Main Methods:

  • Prospective evaluation of liver transplant recipients.
  • Documentation of focal peripheral nerve lesions in the postoperative period.
  • Analysis of potential causes including intraoperative events and postoperative trauma.

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Main Results:

  • 10% of OLT recipients developed focal peripheral nerve lesions postoperatively.
  • The ulnar nerve was the most frequently affected, with compression or trauma as likely causes.
  • Other upper extremity mononeuropathies were associated with vascular cannulations; no brachial plexus injuries were observed.

Conclusions:

  • Mononeuropathies are a notable complication after OLT, with the ulnar nerve being most susceptible.
  • Mechanisms include intraoperative compression, postoperative trauma, and vascular cannulation.
  • Diabetes and alcoholism were not identified as risk factors for these nerve injuries.