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Aqueous ascorbate concentration in hereditary buphthalmic rabbits

K W Lam, P Lee, R Fox

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |September 1, 1976
    PubMed
    Summary
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    Aqueous humor ascorbate levels decrease in rabbits with buphthalmia, a condition linked to glaucoma. This biochemical change in ascorbate concentration is associated with the pathological development of buphthalmia in AXBU/J rabbits.

    Area of Science:

    • Ophthalmology
    • Biochemistry
    • Genetics

    Background:

    • Buphthalmia is a condition affecting the eye, often associated with glaucoma.
    • The AXBU/J rabbit strain exhibits a genetic predisposition to buphthalmia.
    • Understanding biochemical changes in aqueous humor can provide insights into disease mechanisms.

    Purpose of the Study:

    • To investigate aqueous humor constituents in buphthalmic rabbits.
    • To determine the relationship between ascorbate concentration and buphthalmia severity.
    • To explore potential biochemical markers for buphthalmia.

    Main Methods:

    • Analysis of aqueous humor from buphthalmic (bu/bu) AXBU/J rabbits and control AX/J rabbits.
    • Quantification of ascorbate, protein, and ion concentrations in aqueous humor samples.

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  • Correlation of biochemical findings with clinical signs of glaucoma.

    • Main Results:

    • Normal AX/J rabbits had an average aqueous humor ascorbate concentration of 22.5 mg/100ml.
    • Buphthalmic rabbits without clinical signs showed reduced ascorbate levels (11.7 mg/100ml).
    • Rabbits with mild to severe glaucoma exhibited significantly lower ascorbate concentrations (8.9 mg/100ml and 1.9 mg/100ml, respectively).

    Conclusions:

    • Reduced aqueous humor ascorbate is a biochemical alteration associated with buphthalmia development in AXBU/J rabbits.
    • The findings suggest a link between ascorbate depletion and the pathological progression of buphthalmia.
    • The precise mechanism underlying ascorbate reduction in buphthalmia requires further investigation.