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Updated: Jul 31, 2026
14:56
An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
Published on: January 27, 2010
Single-dose dextropropoxyphene in post-operative pain: a quantitative systematic review
S L Collins1, J E Edwards, R A Moore
1Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Headington, United Kingdom.
European Journal of Clinical Pharmacology
|June 17, 1998
Summary
Dextropropoxyphene with paracetamol offers effective pain relief for moderate to severe post-operative pain. This combination shows comparable efficacy to tramadol but with fewer adverse effects, though ibuprofen may be more effective.
Area of Science:
- Pharmacology
- Pain Management
- Clinical Trials
Background:
- Post-operative pain management is crucial for patient recovery.
- Assessing the efficacy and safety of analgesics is essential.
Purpose of the Study:
- To evaluate the analgesic effectiveness and adverse events of single-dose oral dextropropoxyphene, alone and with paracetamol.
- To compare these treatments for moderate to severe post-operative pain.
Main Methods:
- Systematic review of published reports from multiple electronic databases.
- Extracted pain intensity and relief data, calculating the number-needed-to-treat (NNT) for 50% pain relief.
- Compared dextropropoxyphene (65 mg) and dextropropoxyphene (65 mg) plus paracetamol (650 mg) against placebo.
Main Results:
- Dextropropoxyphene 65 mg had an NNT of 7.7 for 50% pain relief.
- Dextropropoxyphene 65 mg plus paracetamol 650 mg had an NNT of 4.4.
- The combination therapy showed an increased incidence of central nervous system adverse effects compared to placebo.
Conclusions:
- Dextropropoxyphene 65 mg plus paracetamol 650 mg demonstrates comparable analgesic efficacy to tramadol 100 mg with a better safety profile.
- Ibuprofen 400 mg exhibited a superior NNT compared to both dextropropoxyphene/paracetamol and tramadol.
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