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Related Experiment Videos

Intralymphocyte free magnesium and plasma triglycerides

P Delva1, C Pastori, M Degan

  • 1Institute of Internal Medicine, University of Verona, Policlinico Borgo Roma, Italy. delvap@borgoroma.univr.it

Life Sciences
|June 17, 1998
PubMed
Summary

High triglycerides, not hypertension, significantly reduce intralymphocyte magnesium (Mg(i)). This finding suggests hypertriglyceridemia is linked to low Mg(i) levels, potentially indicating plurimetabolic syndrome.

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Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Human Physiology

Background:

  • Intralymphocyte magnesium (Mg(i)) is crucial for cellular functions.
  • Hypertension and hypertriglyceridemia are common metabolic conditions.
  • The interplay between these conditions and Mg(i) requires further investigation.

Purpose of the Study:

  • To determine the independent effects of hypertension and hypertriglyceridemia on intralymphocyte magnesium (Mg(i)) levels.
  • To investigate the correlation between plasma triglycerides and Mg(i).

Main Methods:

  • Ionized intralymphocyte magnesium (Mg(i)) concentration was measured using a fluorimetric method (Furaptra dye).
  • Subjects were divided into four groups: normotensive normotriglyceridemic controls, hypertriglyceridemic normotensive patients, hypertriglyceridemic essential hypertensive patients, and normotriglyceridemic essential hypertensive patients.

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  • Exclusion criteria included hypercholesterolemia, diabetes, and alcoholism.

    • Main Results:

    • Mg(i) was significantly reduced in hypertriglyceridemic (HTN) and hypertriglyceridemic essential hypertensive (HTEH) groups compared to controls.
    • No significant difference in Mg(i) was observed between normotensive normotriglyceridemic controls (NTNC) and normotriglyceridemic essential hypertensive patients (NTEH).
    • A significant negative correlation was found between Mg(i) and plasma triglycerides across all subjects.

    Conclusions:

    • Hypertriglyceridemia, independent of hypertension, is associated with reduced intralymphocyte magnesium (Mg(i)).
    • Low intralymphocyte magnesium may be a characteristic of hypertriglyceridemia and potentially the plurimetabolic syndrome.
    • These findings highlight the importance of managing triglyceride levels for maintaining cellular magnesium homeostasis.