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The simulation of density-dependent effects in the recirculation of T lymphocytes
1Department of Zoology, University of Oxford, UK.
Scandinavian Journal of Immunology
|June 17, 1998
Abstract:
T-lymphocyte recirculation appears to be slower in nude or irradiated rats as compared with normal rats. A mathematical model of T-lymphocyte recirculation that incorporates interactions between T cells and dendritic cells in the lymphoid tissue is presented. It is shown that these interactions are able to explain the differences in recirculation times between normal and nude or irradiated rats, and also the time-scales seen in long-term thoracic duct cannulations.