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Leprosy and renal transplantation

A Date1, G T John, P P Thomas

  • 1Department of Pathology, Christian Medical College & Hospital, Vellore, India.

Leprosy Review
|June 17, 1998
PubMed
Summary

Leprosy can occur before or after kidney transplants. Immunosuppression did not hinder leprosy treatment in these renal transplant patients, though one case required rifampicin cessation due to liver issues.

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Immunology

Background:

  • Renal transplantation is a life-saving procedure for end-stage renal disease.
  • Immunosuppression is critical post-transplant to prevent organ rejection.
  • Leprosy is a chronic infectious disease caused by Mycobacterium leprae.

Observation:

  • This study describes nine cases of leprosy in patients at a South Asian renal transplant center.
  • Three patients had pre-existing leprosy, one experienced exacerbation post-transplant.
  • Five patients developed new-onset leprosy between 22 months and 12 years after transplantation.

Findings:

  • Immunosuppressive therapy did not negatively impact leprosy treatment outcomes in these patients.
  • Leprosy can manifest before, during, or long after renal transplantation.
  • Concurrent liver disease necessitated rifampicin discontinuation in one patient.

Implications:

  • Renal transplant recipients may be susceptible to leprosy, requiring vigilant monitoring.
  • Early diagnosis and treatment of leprosy are crucial in immunocompromised patients.
  • Understanding leprosy's interaction with immunosuppression informs long-term transplant care.

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