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Related Experiment Videos

Tissue ascorbic acid and polyol pathway metabolism in experimental diabetes

R M Lindsay1, N S Jamieson, S A Walker

  • 1University of Edinburgh Department of Medicine, Western General Hospital, UK.

Diabetologia
|June 17, 1998
PubMed
Summary

Diabetes reduces ascorbic acid (AA) levels in the kidneys and eyes, but not nerves. Supplementation with AA improved these tissue concentrations, suggesting a potential benefit for diabetic complications.

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Area of Science:

  • Biochemistry
  • Endocrinology
  • Nutritional Science

Background:

  • Reduced plasma ascorbic acid (AA) in diabetes is linked to complications.
  • Limited data exists on tissue AA concentrations in diabetic complications.

Purpose of the Study:

  • Investigate tissue AA concentrations in diabetic animal models.
  • Assess the impact of insulin and AA treatment on these concentrations.

Main Methods:

  • Utilized streptozotocin (STZ)-diabetic and spontaneously diabetic BB rats.
  • Measured AA concentrations in plasma, kidneys, sciatic nerves, and lenses.
  • Evaluated effects of insulin and AA supplementation.

Main Results:

  • Renal and lens AA concentrations were reduced in diabetic rats.

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  • Insulin partially corrected these deficits; AA supplementation normalized them.
  • Sciatic nerve AA levels and oxidative stress markers remained unaffected.

    • Conclusions:

    • Disturbed AA metabolism may contribute to diabetic microangiopathy.
    • AA supplementation shows potential for treating renal and ocular diabetic complications.