Related Experiment Video

Updated: Sep 8, 2026

Mass Histology to Quantify Neurodegeneration in Drosophila
06:34

Mass Histology to Quantify Neurodegeneration in Drosophila

Published on: December 15, 2016

Contribution of the ICE family to neurodegeneration

B D Shivers1, P A Boxer, K M Keane

  • 1Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105, USA. Shiverb@aa.wl.com

Annals of the New York Academy of Sciences
|June 18, 1998
PubMed

Insights

The ICE family of cysteine proteases plays a role in cell death and may be a therapeutic target for neurodegenerative diseases. Inhibitors of these proteases could offer new treatment options for conditions affecting the nervous system.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • The ICE (inter-ICE) family of cysteine proteases are key regulators of cell death pathways.
  • These proteases are implicated in both necrosis and apoptosis.
  • Their involvement extends to the nervous system and other tissues.

Purpose of the Study:

  • To explore the therapeutic potential of ICE family protease inhibitors in neurodegenerative diseases.
  • To consider the role of ICE proteases in cell proliferation and differentiation.
  • To guide the development of novel therapeutics targeting these enzymes.

Main Methods:

  • This abstract does not specify methods.
  • Further research would involve biochemical assays and cellular/in vivo models.

Main Results:

  • The ICE family of cysteine proteases mediates necrotic or apoptotic events.
  • ICE proteases are involved in nervous system functions.
  • Some ICE family members may respond to signals controlling proliferation or differentiation.

Conclusions:

  • ICE family proteases are significant targets for therapeutic intervention in neurodegenerative conditions.
  • Inhibitors may be valuable for treating acute and chronic neurological disorders.
  • Understanding their role in proliferation and differentiation is crucial for therapeutic development.

More Related Videos

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

Related Concept Videos

Glial Cells01:04

Glial Cells

Overview
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...