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Related Experiment Videos

Inflammatory disease as chronic stress

N Shanks1, M S Harbuz, D S Jessop

  • 1Department of Medicine, University of Bristol, United Kingdom. N.Shanks@bristol.ac.uk

Annals of the New York Academy of Sciences
|June 18, 1998
PubMed
Summary

Chronic inflammation alters brain-body communication, changing stress responses and potentially contributing to neuropsychiatric and stress-related diseases.

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The effect of hypothalamic lesions on hypothalamo-pituitary-adrenal axis activity and inflammation in adjuvant-induced arthritis.

Stress (Amsterdam, Netherlands)·2012

Area of Science:

  • Neuroendocrinology
  • Immunology
  • Psychoneuroimmunology

Background:

  • Bidirectional communication exists between the central nervous system (CNS) and immune system.
  • Endocrine factors and immune responses influence each other and the CNS.
  • Inflammation shares similarities with acute stress but diverges in chronic conditions.

Purpose of the Study:

  • To investigate hypothalamic regulation during chronic inflammation.
  • To examine alterations in the hypothalamic-pituitary-adrenal (HPA) axis during chronic inflammation.
  • To explore the role of neuropeptides in the CNS-immune interaction during disease.

Main Methods:

  • Utilized the adjuvant-induced arthritis (AA) model in rodents.
  • Analyzed messenger RNA (mRNA) expression of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) in the paraventricular nucleus (PVN).

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  • Assessed HPA axis responses to psychological and inflammatory stressors.

    • Main Results:

    • Chronic inflammation (AA) showed reduced CRH mRNA and increased AVP mRNA in the PVN, suggesting altered hypothalamic regulation.
    • HPA axis responses to psychological stress were dampened, while responses to inflammatory challenges were maintained.
    • Similar alterations in PVN peptide mRNA were observed in murine models of systemic lupus erythematosus (SLE).

    Conclusions:

    • Altered PVN peptide colocalization may regulate inflammatory responses and stress-system adaptation.
    • Inflammation-induced hypothalamic changes impact stress-responsive systems.
    • Dysregulated CRH in the PVN during inflammation may contribute to neuropsychiatric and stress-related disorders.