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[Fibrinogen as independent risk factor for ischemic stroke]
M M Fukujima1, T L Martinez, L E Pinto
1Universidade Federal de São Paulo, Disciplina de Neurologia, Brasil. Maiumi@sti.com.br
Arquivos De Neuro-Psiquiatria
|June 18, 1998
Summary
Elevated fibrinogen levels are linked to increased risk of atherothrombotic ischemic stroke, particularly in patients with reduced carotid blood flow. This finding highlights fibrinogen as a potential independent risk factor.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Hematology
Context:
- Atherothrombotic ischemic stroke is a leading cause of disability and mortality.
- Identifying thrombotic risk factors is crucial for stroke prevention.
- Fibrinogen is a key protein in blood coagulation and has been implicated in cardiovascular disease.
Purpose:
- To investigate the association between fibrinogen levels and atherothrombotic ischemic stroke.
- To determine if fibrinogen acts as an independent risk factor for stroke.
- To explore the role of fibrinogen in patients with varying degrees of carotid artery stenosis.
Summary:
- This study analyzed fibrinogen levels in 29 patients with atherothrombotic ischemic stroke using the Clauss technique.
- Patients were divided into two groups based on carotid Doppler ultrasonography: without carotid flow reduction (n=19) and with carotid flow reduction (n=10).
- Mean fibrinogen levels were 269 mg/dl in the group without flow reduction and 353 mg/dl in the group with flow reduction. Significantly higher proportions of patients with elevated fibrinogen (>300 mg/dl) were observed in the group with reduced carotid flow (80% vs. 47%).
Impact:
- The findings suggest that elevated fibrinogen levels, especially above 300 mg/dl, may serve as an independent risk factor for atherothrombotic ischemic stroke.
- This is particularly relevant for patients experiencing reduced carotid blood flow.
- These results could inform clinical risk assessment and therapeutic strategies for stroke prevention.