Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Blood-brain barrier evaluation in bone marrow transplantation]

S M de Almeida1, J A Livramento, R Passqüini

  • 1Serviço de TMO, Hospital de Clínicas, Universidade Federal do Paraná (HC-UFPR), Curitiba, Brasil.

Arquivos De Neuro-Psiquiatria
|June 18, 1998
PubMed
Summary

The blood-brain barrier (BBB) remained intact in patients with chronic graft-versus-host disease (GVHD) after allogeneic bone marrow transplants. This study found no evidence of BBB disruption in cerebrospinal fluid proteins, suggesting no central nervous system involvement in chronic GVHD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From guidelines to current practices: Suboptimal hypertension management in France.

Journal de medecine vasculaire·2023
Same author

T-type Ca2+ channels and their relationship with pre-neoplastic and neoplastic lesions in the human breast.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2023
Same author

Analysis of relationship of psychosocial factors with patient safety culture in a Brazilian hospital: Study with structural equation modeling analysis.

Journal of healthcare quality research·2022
Same author

Patients with laboratory criteria of anti-phospholipid syndrome and 'non-criteria' manifestations: a multicenter cohort.

Scandinavian journal of rheumatology·2022
Same author

Expression of VCAN and its receptors in canine mammary carcinomas with or without myoepithelial proliferation.

Research in veterinary science·2021
Same author

Extracapsular extension and tumor implants in lymph nodes with canine mammary carcinoma metastasis: Study of the impact on survival.

Research in veterinary science·2021

Area of Science:

  • Neuroimmunology
  • Hematopoietic Stem Cell Transplantation
  • Transplant Immunology

Context:

  • The blood-brain barrier (BBB) maintains central nervous system (CNS) immune privilege.
  • Chronic graft-versus-host disease (GVHD) is a potential complication following allogeneic bone marrow transplantation (BMT).
  • CNS involvement in chronic GVHD has not been previously investigated regarding BBB integrity.

Purpose:

  • To investigate the integrity of the blood-brain barrier (BBB) in patients with chronic GVHD post-BMT.
  • To determine the incidence and potential pathophysiology of CNS involvement in chronic GVHD.
  • To analyze cerebrospinal fluid (CSF) proteins for evidence of BBB disruption.

Summary:

  • This study analyzed 33 CSF and serum samples from chronic myeloid leukemia patients before and after BMT, and during chronic GVHD.

Related Experiment Videos

  • Quantitative and graphical analysis of CSF proteins was performed to assess BBB function.
  • No evidence of BBB disruption was found in any of the patients studied, irrespective of BMT status or chronic GVHD.

    • Impact:

    • This research provides novel insights into the lack of CNS involvement via BBB disruption in chronic GVHD.
    • Findings suggest that the BBB effectively protects the CNS from systemic immune responses in this context.
    • Establishes a baseline for future research on CNS complications in BMT recipients.