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[Dysembryoplastic neuroepithelial tumor. Case report]

L F Torres1, B Werner, D S Souza

  • 1Serviço de Anatomia Patológica, Hospital Nossa Senhora das Graças, Curitiba, Brasil.

Arquivos De Neuro-Psiquiatria
|June 18, 1998
PubMed
Summary

Dysembryoplastic neuroepithelial tumor (DNT) is a rare brain tumor. This case report details the first Latin-American DNT diagnosis in a young woman with refractory epilepsy.

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Area of Science:

  • Neuro-oncology
  • Epileptology
  • Neuropathology

Background:

  • Dysembryoplastic neuroepithelial tumor (DNT) is a rare neuroepithelial neoplasm.
  • DNT was first described in 1988 and incorporated into the WHO classification in 1993.
  • This study presents the first reported case of DNT in Latin-American literature.

Observation:

  • A 16-year-old female presented with complex partial seizures since age five.
  • Anti-epileptic drug treatment provided incomplete seizure control.
  • Magnetic resonance imaging revealed a left temporal lobe lesion.

Findings:

  • Surgical resection of the temporal lobe lesion was performed.
  • Histological examination confirmed the tumor as DNT, showing atypical neuroglial proliferation.

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  • Immunohistochemistry confirmed both glial (GFAP, S-100) and neuronal (NSE, synaptophysin) components.

    • Implications:

    • This case highlights DNT as a cause of refractory epilepsy in adolescents.
    • Accurate diagnosis and surgical management are crucial for DNT.
    • Further research into DNT pathogenesis and treatment is warranted.