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[Obesity and thrombotic vascular diseases]
1Zentrum für Frauenheikunde, Universitätsklinikum Essen.
Zentralblatt Fur Gynakologie
|June 18, 1998
Summary
Obesity, indicated by increased BMI or abnormal fat distribution (WHR), is linked to metabolic syndrome and heart disease risk. Increased BMI also weakly predicts venous thrombotic disease, especially with other risk factors.
Area of Science:
- Endocrinology
- Cardiology
- Vascular Medicine
Context:
- Obesity presents as elevated Body Mass Index (BMI) or abnormal waist-to-hip ratio (WHR).
- Abnormal fat distribution (increased WHR) is linked to metabolic syndrome, a major ischemic heart disease risk factor.
- Visceral obesity is common in polycystic ovary syndrome and post-menopausal weight gain.
Purpose:
- To elucidate the distinct clinical implications of obesity defined by BMI versus WHR.
- To highlight the association of abnormal fat distribution with metabolic syndrome and cardiovascular risk.
- To identify obesity as a risk marker for venous thrombotic disease.
Summary:
- Increased BMI (>30 kg/m2) serves as a detectable, albeit weak, risk marker for venous thrombotic disease.
- Abnormal fat distribution (WHR) is strongly associated with metabolic syndrome, characterized by glucose intolerance, hypertriglyceridemia, and hypertension.
- Obesity exacerbates risks for venous disease associated with pregnancy, surgery, and estrogen therapy.
Impact:
- Recognizing obesity's dual indicators (BMI and WHR) improves risk stratification for cardiovascular and venous diseases.
- Understanding the link between visceral obesity and metabolic syndrome aids in managing polycystic ovary syndrome and post-menopausal health.
- Clinical awareness of obesity as a venous thrombotic risk factor, particularly when combined with other precipitants, is crucial for preventative care.