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[Reference values for carboxyhemoglobin]

M E de Siqueira1, I Martins, A C Costa

  • 1Departamento de Análises Clínicas, Escola de Farmácia e Odontologia de Alfenas, MG, Brasil. siqueira@artefinal.com.br

Revista De Saude Publica
|June 18, 1998
PubMed
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This study established reference values for carboxyhemoglobin (COHb) in South Minas Gerais, Brazil. The findings provide crucial benchmarks for monitoring occupational exposure to carbon monoxide.

Area of Science:

  • Occupational Health and Environmental Medicine
  • Biomonitoring and Toxicology
  • Clinical Chemistry

Context:

  • Reference values (RV) are essential for interpreting biological indicators in individuals exposed to chemical agents.
  • The Brazilian Group for the Establishment of Reference Values aims to define RVs for various bioindicators across different regions.
  • This study focuses on determining the RV for carboxyhemoglobin (COHb) specifically for the South of Minas Gerais region.

Purpose:

  • To determine the reference values for carboxyhemoglobin (COHb) in a non-smoking population from South Minas Gerais, Brazil.
  • To establish a benchmark for assessing occupational exposure to carbon monoxide (CO) in this specific region.
  • To evaluate the influence of factors like sex, age, and alcohol consumption on COHb levels.

Summary:

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  • Carboxyhemoglobin (COHb) levels were analyzed in 200 non-smoking volunteers using the Beutler and West spectrophotometric method.
  • The mean COHb value was 1.0% ± 0.75, with a 95% confidence interval of 0.9-1.1% and an upper reference value of 2.5%.
  • No statistically significant differences in COHb levels were found based on sex, age, or alcohol consumption.

Impact:

  • Provides essential reference values for carboxyhemoglobin, aiding in the accurate interpretation of biomonitoring results for workers in South Minas Gerais.
  • Contributes to the national effort in establishing standardized reference values for biological indicators in Brazil.
  • Facilitates improved occupational health surveillance and risk assessment for carbon monoxide exposure.