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Autonomic function in manganese alloy workers

W W Barrington1, C R Angle, N K Willcockson

  • 1University of Nebraska Medical Center, Omaha 68198-6055, USA.

Environmental Research
|June 19, 1998
PubMed
Summary
This summary is machine-generated.

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Manganese exposure in welders may impair autonomic nervous system function, leading to decreased heart rate variability and cognitive issues. Further monitoring is recommended for workers exposed to manganese alloys.

Area of Science:

  • Occupational Health
  • Neurotoxicology
  • Cardiovascular Autonomic Function

Background:

  • Manganese toxicity can manifest as neurological symptoms, including orthostatic hypotension.
  • Welders and machinists working with high manganese alloys are at risk of significant exposure.
  • Previous observations of manganese toxicity prompted an evaluation of cardiovascular and cognitive effects in exposed workers.

Purpose of the Study:

  • To prospectively evaluate cardiovascular autonomic function in manganese alloy welders and machinists.
  • To assess cognitive and emotional neurotoxicity in workers with varying levels of manganese exposure.
  • To identify sensitive indices of central autonomic dysfunction related to manganese exposure.

Main Methods:

  • Utilized 24-hour electrocardiographic (Holter) monitoring to assess heart rate variability (HRV) and power spectrum analysis.

Related Experiment Videos

  • Administered psychological assessments (MMPI, MCMI) and neuropsychological tests (memory, attention, executive function).
  • Collected air manganese samples and analyzed serum/urine manganese levels.

    • Main Results:

    • Five high-manganese exposed workers exhibited abnormal sympathovagal balance with decreased high-frequency HRV.
    • Seven of eight workers reported autonomic dysfunction symptoms and significantly decreased HRV (rMSSD).
    • All subjects displayed mood or affect disturbances, with four showing impaired short-term memory and attention.

    Conclusions:

    • Decreased parasympathetic high-frequency activation of HRV, detected by power spectrum analysis, may indicate central autonomic dysfunction from manganese exposure.
    • Neurotoxicity from welding and grinding high manganese alloys necessitates occupational and neuropsychological surveillance, including Holter monitoring.
    • While manganese is implicated, the contribution of co-exposures to solvents and other metals cannot be ruled out.