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Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats
M S Oitzl1, M Fluttert, E R de Kloet
1Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medical Pharmacology, University of Leiden, P.O. Box 9503, 2300 RA Leiden, Netherlands. m.oitzl@lacdr.leidenuniv.nl
Brain Research
|June 19, 1998
Abstract:
Corticosteroids can facilitate or impair learning and memory processes. We found that the glucocorticoid receptor antagonist RU38486 injected locally into the dorsal hippocampus dose-dependently improved the performance of male Wistar rats in the water maze 24 h after treatment. This observation suggests a discrete specificity of hippocampal glucocorticoid receptors in facilitation of memory.