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Aluminum alters intracellular calcium homeostasis in vitro
L Gandolfi1, M P Stella, P Zambenedetti
1Dipartimento di Scienze Farmaceutiche, Università di Padova, Padova, Italy.
Biochimica Et Biophysica Acta
|June 19, 1998
Abstract:
The present paper reports data regarding the influence of aluminum, at micromolar concentrations, on intracellular calcium homeostasis. Al3+ modifies Ca2+ uptake in the endoplasmic reticulum (ER), accelerates Ca2+ release from mitochondria and strongly inhibits Ca2+-ATPase activity with a consequent high-level calcium accumulation inside the cell. These results suggest that Al3+ neurotoxicity may be related to an alteration of the intracellular calcium regulatory system.