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Folates: supplemental forms and therapeutic applications

G S Kelly1

  • 1gregnd@worldnet.att.net

Alternative Medicine Review : a Journal of Clinical Therapeutic
|June 19, 1998
PubMed
Summary
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Folinic acid, a supplemental folate, is more readily utilized by the body than folic acid. It effectively boosts essential coenzyme levels and offers therapeutic benefits for various conditions.

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Medical Research

Background:

  • Folates are crucial single-carbon donors in vital metabolic pathways, including nucleotide and amino acid synthesis.
  • Oral folates are available as folic acid and folinic acid, with differing metabolic pathways.
  • Folate deficiency is linked to a range of serious health issues, including neurological and developmental disorders.

Purpose of the Study:

  • To compare the metabolic activity and therapeutic efficacy of folinic acid versus folic acid.
  • To elucidate the biochemical roles of folates in human health.
  • To review the clinical applications and benefits of folate supplementation.

Main Methods:

  • Literature review of biochemical functions of folates.
  • Analysis of studies comparing folic acid and folinic acid metabolism.

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  • Compilation of therapeutic outcomes associated with folate supplementation.

    • Main Results:

    • Folinic acid bypasses key metabolic steps, making it more rapidly available than folic acid.
    • Folinic acid demonstrates superior efficacy in boosting coenzyme folate levels in certain contexts.
    • Folic acid supplementation shows benefits in reducing homocysteine, preventing neural tube defects, and potentially in managing other conditions.

    Conclusions:

    • Folinic acid is a more metabolically active and potentially more effective form of folate supplementation.
    • Folate supplementation plays a critical role in preventing birth defects and managing various health conditions.
    • Further research into folate's role in neuropsychiatric disorders and other conditions is warranted.