A case of primary Sjögren's syndrome in combination with chronic mesangiocapillary glomerulonephritis and interstitial nephritis

The authors present an extremely rare case of combination of primary Sjögren's syndrome and chronic glomerulonephritis, which was subsequently found to be mesangiocapillary on pathohistologic examination.

This case of mesangiocapillary glomerulonephritis in combination with interstitial nephritis is characterized in terms of the clinical, laboratory, immunologic and instrumental methods for diagnosis. Percutaneous kidney biopsy was performed and the characteristic findings on light microscopy were recorded.

The therapeutic regimen consisting of pulse therapy with Immunovenin-intact and cyclophosphamide resulted in long-term clinical and laboratory remisson of the glomerulopathy and positively influenced the remaining syndromes.

Pulse therapy with these drugs is an alternative to conventional pathogenetic therapy; it can also be the therapeutic modality of choice in cases similar to the one described here having in mind the long-term therapeutic remission.