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Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora. II. Structural studies
H Hori1, Y Igarashi, T Kajiura
1Faculty of Agriculture, Tamagawa University, Tokyo, Japan.
The Journal of Antibiotics
|June 19, 1998
Abstract:
The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.