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Isolation and structure of an antimitotic cyclic peptide, ustiloxin F: chemical interrelation with a homologous
Y Koiso1, N Morisaki, Y Yamashita
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
The Journal of Antibiotics
|June 19, 1998
Abstract:
Ustiloxin F, a microtubule inhibitor, was isolated as a minor metabolite of Ustilaginoidea virens. The structure was determined from the spectral data and by chemical interrelation to ustiloxin B through reductive removal of the sulfoxide-containing side chain of ustiloxin B to give ustiloxin F. Ustiloxin F inhibited microtubule assembly with an IC50 value of 10.3 microM.