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Synthesis and anti-tubulin activity of ustiloxin D derivatives
N Morisaki1, Y Mitsui, Y Yamashita
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
The Journal of Antibiotics
|June 19, 1998
Abstract:
Ustiloxin D, produced by the rice plant pathogen Ustilaginoidea virens, exhibits potent anti-tubulin activity. In order to elucidate the effects of functional groups in ustiloxin D on its activity, several derivatives were synthesized and their anti-tubulin activities were estimated. The N,N-dimethylamino derivative and the 14-O-methyl derivative were inactive (IC50 > 50 microM). 20-Hydroxymethylated ustiloxin D showed decreased inhibitory activity compared with ustiloxin D.