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Diagnosis of sickle-cell disease by DNA analysis in Nigeria
T A Adewole1, D K Olukoya, A Afonja
1Nigerian Institute of Medical Research, Yaba-Lagos, Nigeria.
The Central African Journal of Medicine
|June 19, 1998
Abstract
Objective:
To compare genotyping of leucocyte DNA by PCR and Dde I with the conventional genotyping of haemoglobin of the same subject.
Design:
Comparative study.
Subjects:
25 adults, 16 males and nine females.
Main Outcome Measures:
Predictability.
Results:
In all cases the results were comparable.
Conclusions:
The technology can be applied locally to prenatal diagnosis of sickle-cell disease by chorionic sampling and, therefore, improve the management of sickle-cell disease in Nigeria.