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Related Experiment Videos

Intermediate filament assembly: fibrillogenesis is driven by decisive dimer-dimer interactions

H Herrmann1, U Aebi

  • 1Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany. H.Herrmann@DKFZ-Heidelberg.de

Current Opinion in Structural Biology
|June 19, 1998
PubMed
Summary
This summary is machine-generated.

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Intermediate filaments, built from fibrous proteins, share a conserved assembly plan. Their precise molecular architecture and assembly intermediates remain key unanswered questions in cell biology.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Intermediate filaments (IFs) are a major cytoskeletal component, crucial for cellular structure and mechanical stability.
  • They are assembled from a diverse multigene family of fibrous proteins with conserved hierarchical assembly principles.
  • Despite low sequence identity, IFs exhibit similar physical properties and dimensions.

Purpose of the Study:

  • To review the current understanding of intermediate filament assembly and molecular architecture.
  • To highlight the progress in understanding their complex expression patterns and clinical relevance.
  • To identify the key unanswered questions regarding IF assembly mechanisms.

Main Methods:

  • Literature review of recent advancements in intermediate filament research.

Related Experiment Videos

  • Analysis of structural and biophysical studies on intermediate filament assembly.
  • Comparison of intermediate filament assembly with other cytoskeletal elements like microfilaments and microtubules.

    • Main Results:

    • Intermediate filaments assemble through a hierarchical process involving coiled-coil formation.
    • Despite sequence variations, IFs achieve remarkable uniformity in filament dimensions and mechanical properties.
    • Significant progress has been made in understanding IF expression and associated diseases.

    Conclusions:

    • The fundamental principles of intermediate filament assembly are conserved across different IF types.
    • The precise molecular architecture of assembly intermediates and the dynamics of filament formation require further investigation.
    • Understanding IF assembly is critical for elucidating their roles in cellular function and disease pathogenesis.