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Updated: Aug 17, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Reducing thrombolytic therapy time delays in the emergency department
Insights
Delays in thrombolytic therapy for acute myocardial infarction (AMI) were reduced through targeted quality improvement strategies. Simple interventions significantly decreased treatment times, improving patient care at Auburn Hospital.
Area of Science:
- Cardiology
- Healthcare Quality Improvement
Background:
- Acute myocardial infarction (AMI) requires timely intervention.
- Delays in thrombolytic therapy administration were identified as a quality issue at Auburn Hospital.
- Australian Council of Health-care Standards guidelines set benchmarks for treatment delays.
Purpose of the Study:
- To audit time delays in thrombolytic therapy for AMI patients.
- To implement and evaluate strategies for reducing these delays.
- To improve the quality of care for AMI patients.
Main Methods:
- Retrospective audit of AMI patients discharged or deceased in 1995.
- Implementation of strategies including dedicated ECG machine, facsimile, readily available thrombolytics (Alteplase/rt-PA), staff education, and streamlined treatment initiation.
- Comparison of median time delays before and after intervention.
Main Results:
- Initial median delay from first ECG to thrombolytic therapy was 55 minutes.
- Following interventions, median delay reduced to 43 minutes by 1997.
- Median delay from symptom onset (chest pain) to triage was 73 minutes.
Conclusions:
- Significant delays in thrombolytic therapy for AMI were observed.
- Simple, targeted strategies effectively reduced treatment administration times.
- Quality improvement initiatives by medical and nursing staff can enhance patient outcomes.
Abstract:
A 1 year (1995) retrospective audit of all patients who were discharged or died, with a primary diagnosis of acute myocardial infarction (AMI) was conducted at Auburn Hospital, a level 4 district hospital in Sydney's western suburbs. After their first echocardiogram (ECG), 21 patients of 129 patients who had a primary diagnosis of AMI in the Emergency Department at this time were given thrombolytic therapy. For eight patients there was a time delay of over 60 min to commencement of thrombolytic therapy. This time delay exceeded the Australian Council of Health-care Standards guidelines and was targeted as a quality improvement activity. The hospital cardiologist convened meetings of medical and nursing staff, to develop an action plan for reducing these delays. The strategies adopted, implemented between April and September 1996, involved (i) keeping the ECG machine in the emergency department at all times, (ii) installing a facsimile machine, (iii) keeping Alteplase (rt-PA) in the emergency department, (iv) staff education, (v) allowing senior medical staff to initiate treatment if the consultant was not readily contactable. Resulting from these initiatives time delays (after first ECG) were reduced from a median time of 55 min in 1995 to a median time delay of 43 min in 1997. This study highlights areas of unnecessary delay in patients receiving thrombolytic therapy and shows that these delays can be reduced by the implementation of relatively simple strategies by medical and nursing staff. Time delays from the development of symptoms (usually chest pain) to arrival at triage were recorded when such a time was specified in the clinical notes. The median delay from the development of chest pain to triage was 73 min.
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