Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Apolipoprotein E function in the nervous system]

K Czyzewski1, A Pfeffer, M Barcikowska

  • 1Kliniki Neurologicznej AM, Warszawie.

Neurologia I Neurochirurgia Polska
|June 19, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SARS-CoV-2 infections in children undergoing anticancer therapy or hematopoietic stem cell transplantation: A multicenter nationwide study.

Scientific reports·2026
Same author

Hematopoietic stem cell transplantation does not increase the risk of infection-related complications for pediatric patients with Hodgkin and non-Hodgkin lymphomas: A multicenter nationwide study.

Transplant infectious disease : an official journal of the Transplantation Society·2020
Same author

Adenovirus infection among pediatric patients with cancer and in pediatric recipients of hematopoietic stem cell: A multicenter nationwide study.

Journal of medical virology·2020
Same author

Multidrug-resistant bacterial infections in children undergoing haematopoietic stem cell transplantation over a 6-year period: analysis of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation.

Journal of applied microbiology·2019
Same author

Incidence, course, and outcome of Clostridium difficile infection in children with hematological malignancies or undergoing hematopoietic stem cell transplantation.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2018
Same author

Incidence of Infectious Complications in Children With Acute Lymphoblastic Leukemia Treated With Hematopoietic Stem Cell Transplantation.

Transplantation proceedings·2017
Same journal

Advances in CSF1R-related disorder: novel mutations, dopaminergic imaging, and overcoming underdiagnosis.

Neurologia i neurochirurgia polska·2026
Same journal

Electrophysiological markers of subclinical central nervous system involvement in patients with non-small-cell lung cancer without brain metastases.

Neurologia i neurochirurgia polska·2026
Same journal

Highlighting the CSF1R mutational spectrum: c.2549C>T variant in late-onset leukoencephalopathy mimicking multiple sclerosis.

Neurologia i neurochirurgia polska·2026
Same journal

Sacroiliac joint manipulation for low back and radicular pain: outcomes in a 100-patient single-center cohort.

Neurologia i neurochirurgia polska·2026
Same journal

Beyond leukodystrophy: parkinsonism and microglial failure in CSF1R p.Ile794Thr.

Neurologia i neurochirurgia polska·2026
Same journal

Genetic screening for CSF1R variants in patients with dementia, parkinsonism, and multiple sclerosis.

Neurologia i neurochirurgia polska·2026
See all related articles

Apolipoprotein E (ApoE) links to Alzheimer's disease risk, particularly the ApoE4 variant. This protein influences lipid transport and neurodegeneration by affecting amyloid and tau pathology.

Area of Science:

  • Neurobiology
  • Biochemistry
  • Genetics

Context:

  • Apolipoprotein E (ApoE) is a crucial protein in plasma and cerebrospinal fluid.
  • It functions as a ligand for low-density lipoprotein receptors, mediating lipid transport in the nervous system.
  • ApoE is synthesized by astrocytes in the brain and macrophages in peripheral nerves.

Purpose:

  • To review the multifaceted roles of ApoE in the nervous system, extending beyond lipid transport.
  • To explore the established link between ApoE and Alzheimer's disease (AD).
  • To discuss recent biochemical findings and potential mechanisms of ApoE's involvement in neurodegeneration.

Summary:

  • ApoE is implicated in Alzheimer's disease, with the ApoE epsilon 4 allele being a significant genetic risk factor.

Related Experiment Videos

  • ApoE4 promotes in vivo and in vitro fibrillogenesis of amyloid beta peptide.
  • ApoE3 interacts with tau protein, potentially modulating its phosphorylation and aggregation into paired helical filaments.

    • Impact:

    • Highlights ApoE's dual role in lipid metabolism and neurodegenerative processes.
    • Provides insights into the molecular mechanisms underlying ApoE's contribution to AD pathogenesis.
    • Discusses the clinical utility of ApoE level estimation and phenotyping in cerebrospinal fluid for AD assessment.