Related Experiment Videos
Iontophoretic transdermal delivery of salbutamol: methyl-orange ion-pair
V P Sant1, A J Khopade, N K Jain
1Bharati Vidyapeeth's Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India.
Abstract:
The influence of pulsed current duty cycle, addition of electrically neutral species and pH on iontophoretic transdermal delivery of an organic ion-pair salbutamol:methyl orange through excised rabbit abdominal skin is described. It was compared with salbutamol sulphate and salbutamol:sulphate ion-pair. It was found that there exists an optimum duty cycle range (1:3-1:4) at which iontophoretic flux of the ion-pair was at a maximum because of partition-electric current synchronization. Addition of mannitol decreases the flux of the ion-pair showing the important role of electroosmosis in ion-pair transport. The extremes of pH decrease the flux rates.