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Caffeine abstinence augments the systolic blood pressure response to adenosine in humans
G A Rongen1, S C Brooks, S Ando
1Division of Cardiology, Mount Sinai Hospital, and Centre for Cardiovascular Research, University of Toronto, Ontario, Canada.
Insights
Caffeine abstinence enhances the systolic blood pressure response to adenosine infusion. This effect increases with longer abstinence periods, impacting clinical research involving adenosine.
Area of Science:
- Cardiovascular Physiology
- Pharmacology
Background:
- Adenosine is a purine nucleoside with significant cardiovascular effects.
- Caffeine is a common stimulant that can influence cardiovascular responses.
- The interaction between caffeine abstinence and adenosine's effects requires further investigation.
Purpose of the Study:
- To investigate the impact of varying durations of caffeine abstinence on cardiovascular responses to adenosine infusion.
- To determine if caffeine withdrawal alters blood pressure and heart rate reactivity to adenosine.
Main Methods:
- Seven healthy males underwent adenosine infusion at escalating doses (35, 70, 140 microg/kg/min).
- Cardiovascular parameters (blood pressure, heart rate) were measured after specific periods of caffeine abstinence (6, 30, 78, 150, 318 hours).
Main Results:
- Caffeine abstinence significantly augmented the systolic pressor response to adenosine.
- The pressor response increased progressively with longer abstinence durations (from -1 +/- 2 mm Hg at 6 hours to +9 +/- 2 mm Hg at 318 hours; p = 0.01).
- No significant alteration in the tachycardic response to adenosine was observed.
Conclusions:
- Prolonged caffeine abstinence potentiates the pressor effects of adenosine.
- These findings have implications for interpreting cardiovascular studies involving adenosine, particularly in individuals with varying caffeine intake.
- Consideration of caffeine abstinence duration is crucial in clinical and research settings utilizing adenosine.
Abstract:
Blood pressure and heart rate responses to adenosine infusion (35, 70, and 140 microg/kg/min, intravenously) were studied in 7 healthy men after 6, 30, 78, 150, and 318 hours of abstinence from regular caffeine use. The finding that caffeine abstinence augmented the systolic pressor response (from -1 +/- 2 mm Hg at 6 hours to +9 +/- 2 mm Hg at 318 hours; p = 0.01) but not the tachycardic response to adenosine has implications for current clinical and research applications of this purine.