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Basal cell carcinoma with ossification

A S Boyd1, L E King

  • 1Department of Medicine (Dermatology), Vanderbilt University, Nashville, Tennessee, USA.

Journal of the American Academy of Dermatology
|June 19, 1998
PubMed
Summary
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Osteoma cutis, or bone in the skin, can occur with basal cell carcinoma. This finding may be more common in patients with underlying medical conditions.

Area of Science:

  • Dermatology
  • Pathology
  • Oncology

Background:

  • Osteoma cutis is the presence of lamellar bone in the skin.
  • It is classified as primary or secondary.
  • This study focuses on osteoma cutis associated with basal cell carcinoma.

Purpose of the Study:

  • To describe the clinical and histopathologic features of patients with osteoma cutis.
  • To investigate the association between osteoma cutis and basal cell carcinoma.

Main Methods:

  • Evaluation of five cases of osteoma cutis and basal cell carcinoma.
  • Collection of detailed clinical information from patients.
  • Histopathologic examination of skin biopsies.

Main Results:

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  • All five patients had significant underlying medical conditions.
  • Two patients received interferon alfa-2b therapy; three had prior electrodesiccation and curettage.
  • Histology revealed nodular or micronodular basal cell carcinomas with bone in the stroma and intratumorally.

Conclusions:

  • Bone formation within basal cell carcinomas is not rare.
  • The prevalence of osteoma cutis may be higher in individuals with medical disorders.