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Analysis of vascularity of human neurofibromas
J L Arbiser1, E Flynn, R L Barnhill
1Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA.
Background:
A common misperception is that the vascularity of a tumor can be determined by its gross appearance. Neurofibromas are grossly white in appearance. The degree of vascularity of neurofibromas has not been determined.
Objective:
The purpose of this study was to determine the extent of neovascularization of neurofibromas.
Methods:
Neurofibromas from patients with neurofibromatosis-1 or spontaneous neurofibromas were stained with antibodies against von Willebrand factor (factor VIII-related antigen) and vascular endothelial growth factor (VEGF).
Results:
Neurofibromas, both spontaneous and congenital, exhibit a high degree of vascularity. In addition, perivascular cells in neurofibromas stain with antibodies to VEGF, an angiogenic factor.
Conclusion:
Neurofibromas, despite their gross appearance, are highly vascular. Their vascularity may be mediated, in part, through the angiogenic factor VEGF.
