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Protection of mice against Plasmodium yoelii sporozoite challenge with P. yoelii merozoite surface protein 1 DNA
S I Becker1, R Wang, R C Hedstrom
1Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20889-5607, USA.
Infection and Immunity
|June 25, 1998
Abstract:
Immunization of mice with DNA vaccines encoding the full-length form and C and N termini of Plasmodium yoelii merozoite surface protein 1 provided partial protection against sporozoite challenge and resulted in boosting of antibody titers after challenge. In C57BL/6 mice, two DNA vaccines provided protection comparable to that of recombinant protein consisting of the C terminus in Freund's adjuvant.