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[CD30 positive large T-cell primary cutaneous lymphoma]

M Marschalkó1, A Szigeti, J Hársing

  • 1Bör-és Nemikórtani Klinika, Semmelweis Orvostudományi Egyetem Budapest.

Orvosi Hetilap
|June 20, 1998
PubMed
Summary

Primary cutaneous CD30-positive large cell lymphoma, a rare skin tumor, typically has a favorable prognosis. This case highlights a rare generalized presentation in a young male, successfully treated with chemotherapy.

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Area of Science:

  • Dermatology
  • Oncology
  • Immunology

Background:

  • Primary cutaneous CD30-positive large cell lymphoma (PCL-DLBCL) is a rare T-cell or B-cell lymphoma primarily affecting the skin.
  • It typically presents as localized skin tumors with a favorable prognosis and rare systemic involvement.

Observation:

  • A 25-year-old male developed generalized skin symptoms including itching and necrotic papules.
  • Two years later, systemic symptoms emerged: fever, fatigue, lymphadenopathy, splenomegaly, elevated white blood cell count with eosinophilia, and increased CD4+ T-cells.

Findings:

  • Histology and immunohistology confirmed diffuse infiltration of large, anaplastic, CD30-positive T-cells in the skin and peripheral lymph nodes.
  • The patient's condition represented a rare generalized manifestation of PCL-DLBCL.

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Implications:

  • This case underscores the importance of considering systemic progression in PCL-DLBCL, even with initial favorable prognosis.
  • Chemotherapy regimens like CHOP and BACOP can effectively manage both cutaneous and systemic symptoms of generalized PCL-DLBCL.