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Related Experiment Videos

Does obesity influence ciprofibrate activity?

J M Silva1, P Serra e Silva

  • 1Serviço de Medicina II, Hospitais da Universidade de Coimbra.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|June 20, 1998
PubMed
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Ciprofibrate appears more effective in obese patients with high triglycerides and low HDL-cholesterol. This study explored obesity

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Obesity is linked to dyslipidemia, including high triglycerides and low HDL-cholesterol.
  • The impact of obesity on hypolipidemic drug efficacy is not well understood.

Purpose of the Study:

  • To investigate the relationship between obesity and the efficacy of ciprofibrate.
  • To determine if obesity influences ciprofibrate's effectiveness in managing dyslipidemia.

Main Methods:

  • Post-hoc analysis of an open-label, 6-month ciprofibrate therapy study.
  • Included patients aged 30-70 with dyslipidemia (high cholesterol/triglycerides).
  • Measured lipids, apoproteins, and fibrinogen before and after ciprofibrate treatment.

Main Results:

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  • Triglyceride levels and their reduction correlated positively with BMI and waist/hip ratio.
  • Baseline HDL-cholesterol correlated negatively with BMI and waist/hip ratio.
  • Ciprofibrate's effect on triglycerides and HDL-cholesterol showed a positive correlation with BMI.

Conclusions:

  • Ciprofibrate may be particularly effective in obese individuals with high triglycerides and low HDL-C.
  • Further research is warranted to confirm ciprofibrate's efficacy in obese dyslipidemic patients.