Related Experiment Video
Updated: Aug 15, 2026

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia
Published on: June 22, 2013
Spontaneous intracranial hypotension resulting in stupor caused by diencephalic compression
S J Pleasure1, A Abosch, J Friedman
1Department of Neurology, University of California, San Francisco School of Medicine, USA.
Abstract:
A 51-year-old man had a 4-month history of progressive headache and gradual onset of somnolence. MRI suggested spontaneous intracranial hypotension (SIH) with diencephalic compression, but he did not improve after three epidural blood patches. He became alert following intrathecal saline infusion that normalized his CSF pressure. A CSF leak was noted on spinal MRI and confirmed with CT contrast myelography. Surgical ligation of a torn dural root sleeve isolating a ruptured Tarlov's cyst resulted in permanent cure.
Related Concept Videos
Hemorrhagic Stroke ll: Pathophysiology
Transient Ischemic Attack l: Introduction
Increased Intracranial Pressure l: Introduction
Increased Intracranial Pressure ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Cytotoxic Edema: Pathophysiology

