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Bladder and urethral innervation in multiple sclerosis

J T Anderson, W E Bradley

    British Journal of Urology
    |August 1, 1976
    PubMed
    Summary
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    Multiple sclerosis (MS) can damage bladder and urethral nerves, often due to spinal cord lesions. This study found nerve signal delays in most MS patients, indicating demyelination affecting bladder control.

    Area of Science:

    • Neuroscience
    • Urology
    • Neurology

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Bladder and urethral dysfunction are common symptoms in MS patients.
    • Innervation pathways are crucial for bladder and urethral function.

    Purpose of the Study:

    • To investigate bladder and urethral innervation in patients with multiple sclerosis.
    • To identify neurological correlates of bladder dysfunction in MS.
    • To assess the impact of demyelinating lesions on specific neural pathways.

    Main Methods:

    • Utilized signal tracing techniques, specifically evoked reflex latency measurements.
    • Studied a cohort of 52 patients diagnosed with multiple sclerosis.
    • Analyzed signal transit times and corticospinal innervation of the pudendal nucleus.

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    Main Results:

    • Prolonged signal transit times were observed in the majority of patients, suggesting demyelinating plaques in the lumbosacral spinal cord.
    • Impairment of corticospinal innervation to the pudendal nucleus was detected in 29 patients.
    • Findings indicate lesions within the pyramidal tract affecting bladder control pathways.

    Conclusions:

    • Bladder and urethral innervation are frequently compromised in multiple sclerosis.
    • Demyelinating lesions in the spinal cord and pyramidal tract are implicated in MS-related bladder dysfunction.
    • Evoked reflex latency measurement is a valuable tool for assessing neurological impact on lower urinary tract symptoms in MS.