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CD5 negative diffuse mantle cell lymphoma with splenomegaly and bone marrow involvement
1Department of Pathology, University of South Alabama Medical Center, Mobile 36617, USA.
Southern Medical Journal
|June 20, 1998
Summary
This case study highlights an unusual CD5-negative mantle cell lymphoma, emphasizing the need for integrated diagnostic approaches including molecular and cytogenetic analysis for accurate lymphoma classification.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma.
- Typical MCL is characterized by CD5 and CD10 negativity and the presence of t(11;14).
- Atypical phenotypes can pose diagnostic challenges.
Observation:
- A 78-year-old man presented with cervical adenopathy and splenomegaly.
- Peripheral blood revealed lymphocytosis with slightly indented nuclei.
- Lymph node and bone marrow biopsies showed lymphoid proliferation.
Findings:
- Immunophenotyping demonstrated CD19+, CD20+, CD22+, lambda-restricted lymphocytes.
- Importantly, CD5 and CD10 were negative.
- Cytogenetic analysis confirmed the characteristic t(11;14) translocation.
Implications:
- This case represents an unusual CD5-negative variant of mantle cell lymphoma.
- Accurate diagnosis requires a combination of morphology, immunophenotyping, and cytogenetics.
- Integrated diagnostic strategies are crucial for managing atypical lymphoma presentations.