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CD44 expression and growth factors

J Hamada1, Y Sawamura, E G Van Meir

  • 1Division of Cell Biology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan. jhamada@med.hokudai.ac.jp

Frontiers in Bioscience : a Journal and Virtual Library
|June 23, 1998
PubMed
Summary

Tumor microenvironment factors influence cancer cell malignancy. Growth factors and cytokines alter CD44 molecule expression and function, impacting tumor cell adhesion, migration, and metastasis.

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Area of Science:

  • Oncology and Molecular Biology
  • Cancer Cell Biology
  • Tumor Microenvironment Research

Background:

  • Soluble factors like growth factors and cytokines in the tumor microenvironment regulate genes linked to cancer malignancy.
  • CD44 is a key adhesion molecule mediating cell interactions and trapping growth factors, influencing cell traffic.
  • These factors modulate CD44 expression, splicing, and function, altering cancer cell properties.

Purpose of the Study:

  • To investigate how tumor microenvironment factors, specifically growth factors and cytokines, influence CD44 expression and function.
  • To understand the role of CD44 modifications in regulating malignant properties of tumor cells.
  • To explore the impact of CD44 alterations on cancer cell adhesion, survival, and metastasis.

Main Methods:

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  • Analysis of gene expression related to tumor malignancy.
  • Investigation of CD44 molecule expression, splicing, and function.
  • Assessment of cancer cell adhesion, migration, invasion, and survival assays.
  • Study of interactions between growth factors, cytokines, and CD44.

Main Results:

  • Growth factors and cytokines significantly alter CD44 expression and isoform splicing.
  • Modified CD44 enhances circulating tumor cell adhesion to endothelium and survival.
  • CD44-mediated growth factor presentation supports tumor cell survival and progression.
  • Alterations in CD44 on tumor and host cells contribute to tumor progression.

Conclusions:

  • Soluble factors in the tumor microenvironment critically regulate CD44, impacting cancer progression.
  • CD44 modifications play a vital role in enhancing tumor cell survival, adhesion, and metastatic potential.
  • Targeting CD44-mediated signaling pathways could offer therapeutic strategies for cancer treatment.