Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokines and tear function in ocular surface disease

K Barton1, A Nava, D C Monroy

  • 1Corneal and External Disease Service, Bascom Palmer Eye Institute, University of Miami School of Medicine, Florida, USA.

Advances in Experimental Medicine and Biology
|June 23, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Constraints on General Neutrino Interactions Based on KATRIN Data.

Physical review letters·2025
Same author

Correction: 'Dental cementum virtual histology of Neanderthal teeth from Krapina (Croatia, 130-120 kyr): an informed estimate of age, sex and adult stressors' (2022), by Cerrito <i>et al.</i>

Journal of the Royal Society, Interface·2024
Same author

Differences in the Surgical Outcomes of Glaucoma Surgery in Patients of African Caribbean Descent.

Current eye research·2022
Same author

Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation.

Science advances·2020
Same author

A5 Peripheral blood cells contribute to HIV-1 viremia induced by romidepsin.

Virus evolution·2017
Same author

Leaf size, specific leaf area and microhabitat distribution of chaparral woody plants: contrasting patterns in species level and community level analyses.

Oecologia·2017

Tear epidermal growth factor (EGF) levels link to tear production in healthy eyes, suggesting a regulatory system. In ocular rosacea, elevated IL-1 alpha may worsen inflammation due to reduced tear flow.

Area of Science:

  • Ophthalmology
  • Biochemistry
  • Immunology

Background:

  • Tear film homeostasis is crucial for ocular surface health.
  • Epidermal Growth Factor (EGF) plays a role in maintaining the ocular surface.
  • Ocular rosacea shares symptoms with dry eye disease (keratoconjunctivitis sicca).

Purpose of the Study:

  • To investigate the correlation between tear epidermal growth factor (EGF) levels and tear production in normal individuals.
  • To assess the reliability of commercial ELISA kits for measuring tear EGF.
  • To examine the levels of inflammatory cytokine IL-1 alpha in the tear fluid of patients with ocular rosacea.

Main Methods:

  • Correlation analysis of tear EGF levels and tear production in healthy subjects.
  • Evaluation of commercial ELISA kits for tear EGF measurement consistency.

Related Experiment Videos

  • Measurement of tear IL-1 alpha levels in patients with ocular rosacea compared to controls.

    • Main Results:

    • Tear EGF levels showed a strong positive correlation with tear production in normal individuals.
    • Commercial ELISA kits demonstrated good consistency in measuring tear EGF.
    • Patients with ocular rosacea exhibited elevated tear levels of the inflammatory cytokine IL-1 alpha.

    Conclusions:

    • A homeostatic mechanism likely regulates tear EGF supply to the ocular surface.
    • Commercial ELISA kits are potentially valuable for standardizing tear EGF measurements across studies.
    • Reduced tear turnover in ocular rosacea may contribute to elevated IL-1 alpha, promoting inflammation.