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Novel thiazolidinedione derivatives with retinoid synergistic activity
M Ebisawa1, E Kawachi, H Fukasawa
1Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
Biological & Pharmaceutical Bulletin
|June 23, 1998
Abstract:
Several arylmethylidene thiazolidinediones were synthesized and their retinoidal activities were examined. TZ181 (7a), having a benzanilide skeleton, exhibited differentiation-inducing activity in HL-60 cell assay, while TZ191 (7b), the N-methylated analog of TZ181 (7a), TZ245 (9) and TZ335 (10) acted as retinoid synergists like the RXR-selective ligand, LGD1069 (5).